Assay Detail
Binding
CHEMBL4158858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FITC-geldanamycin binding to HSP90alpha (unknown origin) incubated for 5 hrs by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 6.14 | 6.21 |
| IC50 | 2 | 4.41 | 4.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426787 | — | — | 1 | 6.21 |
| CHEMBL3426786 | — | — | 1 | 6.06 |
| CHEMBL4159086 | — | — | 1 | 4.41 |
| CHEMBL4168274 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426787 | — | Kd | = | 620.0 | nM | 6.21 |
| CHEMBL3426786 | — | Kd | = | 870.0 | nM | 6.06 |
| CHEMBL4159086 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL4168274 | — | IC50 | > | 100000.0 | nM | - |