Assay Detail
Functional
CHEMBL4158878
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of erastin-induced ferroptosis in human IMR32 cells preincubated for 1 hr followed by erastin stimulation and measured after 13 hrs by sytox green-based fluorescence assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.85 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168993 | — | — | 1 | 8.52 |
| CHEMBL4171787 | — | — | 1 | 8.00 |
| CHEMBL4161069 | — | — | 1 | 7.92 |
| CHEMBL4175796 | — | — | 1 | 7.66 |
| CHEMBL4165647 | — | — | 1 | 7.62 |
| CHEMBL3633556 | — | — | 1 | 7.48 |
| CHEMBL4166618 | — | — | 1 | 7.01 |
| CHEMBL4176836 | — | — | 1 | 6.95 |
| CHEMBL4174533 | — | — | 1 | 6.80 |
| CHEMBL4166181 | — | — | 1 | 6.80 |
| CHEMBL4159412 | — | — | 1 | 6.72 |
| CHEMBL4159369 | — | — | 1 | 6.67 |
| CHEMBL4161678 | — | — | 1 | 6.63 |
| CHEMBL4169410 | — | — | 1 | 6.53 |
| CHEMBL4177259 | — | — | 1 | 6.51 |
| CHEMBL4166219 | — | — | 1 | 6.36 |
| CHEMBL4169606 | — | — | 1 | 6.35 |
| CHEMBL4170004 | — | — | 1 | 6.31 |
| CHEMBL4159421 | — | — | 1 | 6.26 |
| CHEMBL4171852 | — | — | 1 | 5.97 |
| CHEMBL4170037 | — | — | 1 | 5.82 |
| CHEMBL4165118 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168993 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4171787 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4161069 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4175796 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4165647 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3633556 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4166618 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4176836 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4174533 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL4166181 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4159412 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL4159369 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL4161678 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL4169410 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL4177259 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL4166219 | — | IC50 | = | 442.0 | nM | 6.36 |
| CHEMBL4169606 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL4170004 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL4159421 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL4171852 | — | IC50 | = | 1072.0 | nM | 5.97 |
| CHEMBL4170037 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4165118 | — | IC50 | = | 1560.0 | nM | 5.81 |