Assay Detail
Binding
CHEMBL4178007
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Inhibition of Cryptosporidium parvum CDPK1 using PLARTLSVAGLPGKK peptide as substrate by NADH coupled LDH-PK ATPase assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cryptosporidium parvum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.51 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208125 | — | — | 1 | 7.72 |
| CHEMBL4218785 | — | — | 1 | 7.14 |
| CHEMBL4214870 | — | — | 1 | 7.13 |
| CHEMBL365663 | GW780159X | — | 1 | 7.08 |
| CHEMBL4209540 | — | — | 1 | 6.72 |
| CHEMBL4206097 | — | — | 1 | 6.72 |
| CHEMBL4205167 | — | — | 1 | 6.68 |
| CHEMBL361237 | GW785804X | — | 1 | 6.66 |
| CHEMBL4212444 | — | — | 1 | 6.58 |
| CHEMBL4211693 | — | — | 1 | 6.48 |
| CHEMBL4209953 | — | — | 1 | 6.46 |
| CHEMBL4217687 | — | — | 1 | 6.43 |
| CHEMBL4209312 | — | — | 1 | 6.40 |
| CHEMBL4204551 | — | — | 1 | 6.35 |
| CHEMBL4216667 | — | — | 1 | 5.82 |
| CHEMBL4217402 | — | — | 1 | 5.82 |
| CHEMBL4212736 | — | — | 1 | 5.58 |
| CHEMBL4214228 | — | — | 1 | 5.46 |
| CHEMBL4213278 | — | — | 1 | - |
| CHEMBL4204005 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208125 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4218785 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4214870 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL365663 | GW780159X | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4209540 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4206097 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4205167 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL361237 | GW785804X | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4212444 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4211693 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4209953 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4217687 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL4209312 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4204551 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4216667 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4217402 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4212736 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4214228 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4213278 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4204005 | — | IC50 | > | 10000.0 | nM | - |