Assay Detail
Binding
CHEMBL4178039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells pretreated for 30 mins followed by TGFbeta stimulation measured after overnight incubation by luciferase reporter gene assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365663 | GW780159X | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365663 | GW780159X | IC50 | = | 10.0 | nM | 8.00 |