Assay Detail
Binding
CHEMBL4178542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of African green monkey SOAT2 expressed in CHO cells assessed as reduction in neutral lipid synthesis incubated for 6 hrs using [1-14C]oleic acid by thin-layer chromatography
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Chlorocebus aethiops |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sterol O-acyltransferase 2 (CHEMBL3879854) ↗| Type | SINGLE PROTEIN |
| Organism | Chlorocebus aethiops |
Publication
Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.58 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4212280 | — | — | 1 | 5.89 |
| CHEMBL116226 | — | — | 1 | 5.82 |
| CHEMBL4207391 | — | — | 1 | 5.60 |
| CHEMBL4207917 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4212280 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL116226 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4207391 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4207917 | — | IC50 | = | 9600.0 | nM | 5.02 |