Assay Detail
Binding
CHEMBL4178543
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of African green monkey SOAT1 expressed in CHO cell microsomal fractions assessed as reduction in neutral lipid synthesis incubated for 6 hrs using [1-14C]oleoyl-CoA by thin-layer chromatography
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Chlorocebus aethiops |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sterol O-acyltransferase 1 (CHEMBL3879850) ↗| Type | SINGLE PROTEIN |
| Organism | Chlorocebus aethiops |
Publication
Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.48 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116226 | — | — | 1 | 6.05 |
| CHEMBL4212280 | — | — | 1 | 5.75 |
| CHEMBL4207391 | — | — | 1 | 5.17 |
| CHEMBL4207917 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116226 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4212280 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4207391 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4207917 | — | IC50 | = | 11000.0 | nM | 4.96 |