Assay Detail
Binding
CHEMBL4178567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human PAD2 expressed in HEK293T cells assessed as protein occupancy preincubated for 15 mins followed by ionomycin addition measured after 1 hr in presence of CaCl2 by RIBFA probe based SDS-PAGE analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-arginine deiminase type-2 (CHEMBL1909487) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.04 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4202689 | — | — | 1 | 5.23 |
| CHEMBL4204476 | — | — | 1 | 5.12 |
| CHEMBL4217485 | — | — | 1 | 5.12 |
| CHEMBL4211403 | — | — | 1 | 5.08 |
| CHEMBL4214962 | — | — | 1 | 5.02 |
| CHEMBL4216140 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4202689 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4204476 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4217485 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4211403 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4214962 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4216140 | — | EC50 | = | 20600.0 | nM | 4.69 |