Assay Detail
Binding
CHEMBL4178569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human PAD2 expressed in HEK293T cells assessed as decrease in histone H3 citrulination incubated for 3 hrs in presence of ionomycin/CaCl2 by SDS-PAGE analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-arginine deiminase type-2 (CHEMBL1909487) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.84 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4214962 | — | — | 1 | 6.40 |
| CHEMBL4204476 | — | — | 1 | 5.92 |
| CHEMBL4202689 | — | — | 1 | 5.68 |
| CHEMBL4217485 | — | — | 1 | 5.62 |
| CHEMBL4211403 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4214962 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4204476 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4202689 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4217485 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4211403 | — | EC50 | = | 2700.0 | nM | 5.57 |