Assay Detail
Binding
CHEMBL4178989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced intracellular calcium level preincubated for 6 mins followed by capsaicin addition by Fluo-4 dye based FLIPR assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.47 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3689046 | — | — | 1 | 10.00 |
| CHEMBL3689037 | — | — | 1 | 10.00 |
| CHEMBL4215829 | — | — | 1 | 10.00 |
| CHEMBL3689043 | — | — | 1 | 9.52 |
| CHEMBL3689044 | — | — | 1 | 9.52 |
| CHEMBL3689036 | — | — | 1 | 9.52 |
| CHEMBL3689041 | — | — | 1 | 9.40 |
| CHEMBL3689038 | — | — | 1 | 9.30 |
| CHEMBL3689034 | — | — | 1 | 8.43 |
| CHEMBL4205905 | — | — | 1 | 8.29 |
| CHEMBL4217897 | — | — | 1 | 8.10 |
| CHEMBL3684333 | — | — | 1 | 8.10 |
| CHEMBL3684332 | — | — | 1 | 7.67 |
| CHEMBL3689045 | — | — | 1 | 7.58 |
| CHEMBL3684330 | — | — | 1 | 7.56 |
| CHEMBL3689042 | — | — | 1 | 7.50 |
| CHEMBL4203430 | — | — | 1 | 7.30 |
| CHEMBL3689033 | — | — | 1 | 7.12 |
| CHEMBL4209620 | — | — | 1 | 6.09 |
| CHEMBL4202633 | — | — | 1 | - |
| CHEMBL4205551 | — | — | 1 | - |
| CHEMBL4215629 | — | — | 1 | - |
| CHEMBL4205870 | — | — | 1 | - |
| CHEMBL3689040 | — | — | 1 | - |
| CHEMBL4215102 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3689046 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL3689037 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL4215829 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL3689043 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3689044 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3689036 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3689041 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL3689038 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL3689034 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4205905 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4217897 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL3684333 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL3684332 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL3689045 | — | Ki | = | 26.5 | nM | 7.58 |
| CHEMBL3684330 | — | Ki | = | 27.7 | nM | 7.56 |
| CHEMBL3689042 | — | Ki | = | 31.7 | nM | 7.50 |
| CHEMBL4203430 | — | Ki | = | 50.2 | nM | 7.30 |
| CHEMBL3689033 | — | Ki | = | 75.2 | nM | 7.12 |
| CHEMBL4209620 | — | Ki | = | 819.0 | nM | 6.09 |
| CHEMBL4202633 | — | Ki | - | — | - | |
| CHEMBL4205551 | — | Ki | - | — | - | |
| CHEMBL4215629 | — | Ki | - | — | - | |
| CHEMBL4205870 | — | Ki | - | — | - | |
| CHEMBL3689040 | — | Ki | - | — | - | |
| CHEMBL4215102 | — | Ki | - | — | - |