Assay Detail
Binding
CHEMBL4179027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK3/JAK1 in mouse CTLL-2 cells assessed as reduction in IL2-stimulated STAT5 phosphorylation
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Target
Tyrosine-protein kinase JAK1/JAK3 (CHEMBL3885650) ↗| Type | PROTEIN FAMILY |
| Organism | Mus musculus |
Publication
Recent advances in JAK3 inhibition: Isoform selectivity by covalent cysteine targeting.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.16 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3650985 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3650985 | — | IC50 | = | 70.0 | nM | 7.16 |