Assay Detail
Functional
CHEMBL4179110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 assessed as inhibition of cell growth incubated for 48 hrs by resazurin reduction test
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Linker structure-activity relationships in fluorodeoxyglucose chlorambucil conjugates for tumor-targeted chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.92 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208248 | — | — | 1 | 5.47 |
| CHEMBL500328 | — | — | 1 | 5.30 |
| CHEMBL4202444 | — | — | 1 | 5.22 |
| CHEMBL4205591 | — | — | 1 | 5.16 |
| CHEMBL501118 | — | — | 1 | 5.10 |
| CHEMBL4218190 | — | — | 1 | 5.05 |
| CHEMBL4218156 | — | — | 1 | 4.89 |
| CHEMBL4203376 | — | — | 1 | 4.85 |
| CHEMBL4214989 | — | — | 1 | 4.82 |
| CHEMBL447306 | — | — | 1 | 4.80 |
| CHEMBL4209847 | — | — | 1 | 4.50 |
| CHEMBL4215715 | — | — | 1 | 4.46 |
| CHEMBL4205269 | — | — | 1 | 4.40 |
| CHEMBL4207756 | — | — | 1 | - |
| CHEMBL4209326 | — | — | 1 | - |
| CHEMBL4218146 | — | — | 1 | - |
| CHEMBL4218273 | — | — | 1 | - |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208248 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL500328 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4202444 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4205591 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL501118 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4218190 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4218156 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4203376 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4214989 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL447306 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4209847 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4215715 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4205269 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL4207756 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4209326 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4218146 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4218273 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL515 | CHLORAMBUCIL | IC50 | > | 100000.0 | nM | - |