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Assay Detail

CHEMBL4180005

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Trypanosoma cruzi trans-sialidase using Trifluoromethylumbelliferyl alpha-sialoside as substrate by UV/visible spectrophotometer
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Trans-sialidase (CHEMBL4105902)
Type SINGLE PROTEIN
Organism Trypanosoma cruzi

Publication

Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion.
Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-Baruffi M, Carvalho I, Campo VL.
Bioorg Med Chem (2017) 25 : 6049 -6059
PubMed 29032929 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.22 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4205834 1 6.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4205834 IC50 = 600.0 nM 6.22