Assay Detail
Binding
CHEMBL4180100
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Inhibition of recombinant human HCK SH3-SH2-KD (75 to 526 residues) after 20 mins by mobility shift assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.66 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45177 | — | — | 1 | 9.40 |
| CHEMBL4208645 | — | — | 1 | 8.74 |
| CHEMBL4066401 | — | — | 1 | 8.43 |
| CHEMBL4093003 | — | — | 1 | 8.36 |
| CHEMBL4207885 | — | — | 1 | 8.27 |
| CHEMBL4215201 | — | — | 1 | 8.20 |
| CHEMBL4206460 | — | — | 1 | 8.16 |
| CHEMBL4209781 | — | — | 1 | 8.13 |
| CHEMBL4216163 | — | — | 1 | 8.12 |
| CHEMBL4202763 | — | — | 1 | 7.92 |
| CHEMBL4218162 | — | — | 1 | 7.89 |
| CHEMBL4203665 | — | — | 1 | 7.82 |
| CHEMBL4213227 | — | — | 1 | 7.82 |
| CHEMBL4210294 | — | — | 1 | 7.75 |
| CHEMBL4203527 | — | — | 1 | 7.64 |
| CHEMBL4205400 | — | — | 1 | 7.62 |
| CHEMBL4209498 | — | — | 1 | 7.57 |
| CHEMBL4202997 | — | — | 1 | 7.55 |
| CHEMBL4205815 | — | — | 1 | 7.44 |
| CHEMBL4212500 | — | — | 1 | 7.44 |
| CHEMBL4214689 | — | — | 1 | 7.41 |
| CHEMBL4203767 | — | — | 1 | 7.40 |
| CHEMBL4207351 | — | — | 1 | 7.28 |
| CHEMBL4216680 | — | — | 1 | 7.19 |
| CHEMBL4209614 | — | — | 1 | 7.14 |
| CHEMBL4204499 | — | — | 1 | 7.13 |
| CHEMBL4212241 | — | — | 1 | 7.10 |
| CHEMBL4208669 | — | — | 1 | 6.98 |
| CHEMBL4213372 | — | — | 1 | 6.92 |
| CHEMBL4212432 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45177 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4208645 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4066401 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4093003 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4207885 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4215201 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4206460 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4209781 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4216163 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4202763 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4218162 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4203665 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4213227 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4210294 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4203527 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4205400 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4209498 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4202997 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4205815 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4212500 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4214689 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4203767 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4207351 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4216680 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4209614 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4204499 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4212241 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4208669 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4213372 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4212432 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL4211710 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4207785 | — | IC50 | = | 226.0 | nM | 6.65 |