Assay Detail
Functional
CHEMBL4180223
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Antimalarial activity against Plasmodium falciparum 3D7 infected in ARh+ human erythrocytes after 42 to 48 hrs by Picogreen staining-based 96 well microplate assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.13 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217155 | — | — | 1 | 7.55 |
| CHEMBL4205490 | — | — | 1 | 7.54 |
| CHEMBL4217209 | — | — | 1 | 7.54 |
| CHEMBL4207128 | — | — | 1 | 7.41 |
| CHEMBL4204991 | — | — | 1 | 7.30 |
| CHEMBL4213322 | — | — | 1 | 7.11 |
| CHEMBL4208355 | — | — | 1 | 7.07 |
| CHEMBL4208389 | — | — | 1 | 6.96 |
| CHEMBL58025 | — | — | 1 | 6.90 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 6.79 |
| CHEMBL236609 | — | — | 1 | 6.71 |
| CHEMBL4212002 | — | — | 1 | 6.62 |
| CHEMBL59081 | — | — | 1 | 6.46 |
| CHEMBL4212778 | — | — | 1 | 6.38 |
| CHEMBL432296 | — | — | 1 | 6.14 |
| CHEMBL4207613 | — | — | 1 | 6.08 |
| CHEMBL4217373 | — | — | 1 | 6.07 |
| CHEMBL236785 | — | — | 1 | 5.72 |
| CHEMBL4213619 | — | — | 1 | 5.65 |
| CHEMBL61301 | TECASTEMIZOLE | 2.0 | 1 | 5.64 |
| CHEMBL59015 | — | — | 1 | 5.51 |
| CHEMBL4206159 | — | — | 1 | 5.40 |
| CHEMBL4217400 | — | — | 1 | 5.33 |
| CHEMBL4202777 | — | — | 1 | 5.27 |
| CHEMBL4210527 | — | — | 1 | 5.21 |
| CHEMBL4209466 | — | — | 1 | 5.20 |
| CHEMBL4203304 | — | — | 1 | 5.18 |
| CHEMBL4205028 | — | — | 1 | 5.17 |
| CHEMBL4205096 | — | — | 1 | 5.16 |
| CHEMBL4218790 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217155 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4205490 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4217209 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4207128 | — | IC50 | = | 39.4 | nM | 7.41 |
| CHEMBL4204991 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4213322 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4208355 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4208389 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL58025 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL236609 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL4212002 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL59081 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL4212778 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL432296 | — | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL4207613 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL4217373 | — | IC50 | = | 857.0 | nM | 6.07 |
| CHEMBL236785 | — | IC50 | = | 1902.0 | nM | 5.72 |
| CHEMBL4213619 | — | IC50 | = | 2245.0 | nM | 5.65 |
| CHEMBL61301 | TECASTEMIZOLE | IC50 | = | 2304.0 | nM | 5.64 |
| CHEMBL59015 | — | IC50 | = | 3089.0 | nM | 5.51 |
| CHEMBL4206159 | — | IC50 | = | 3956.0 | nM | 5.40 |
| CHEMBL4217400 | — | IC50 | = | 4642.0 | nM | 5.33 |
| CHEMBL4202777 | — | IC50 | = | 5322.0 | nM | 5.27 |
| CHEMBL4210527 | — | IC50 | = | 6178.0 | nM | 5.21 |
| CHEMBL4209466 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL4203304 | — | IC50 | = | 6527.0 | nM | 5.18 |
| CHEMBL4205028 | — | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL4205096 | — | IC50 | = | 6848.0 | nM | 5.16 |
| CHEMBL4218790 | — | IC50 | = | 8142.0 | nM | 5.09 |
| CHEMBL4209978 | — | IC50 | = | 8287.0 | nM | 5.08 |
| CHEMBL4206953 | — | IC50 | = | 10040.0 | nM | 5.00 |
| CHEMBL4208506 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4204167 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4214370 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4213858 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4205611 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4217321 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4207868 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4216701 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4210677 | — | IC50 | > | 10000.0 | nM | - |