Assay Detail
Functional
CHEMBL4180591
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Antiproliferative activity against human COLO205 cells after 96 hrs by CCK-8 assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.48 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4218267 | — | — | 1 | 7.40 |
| CHEMBL4204030 | — | — | 1 | 7.30 |
| CHEMBL4213557 | — | — | 1 | 6.96 |
| CHEMBL4208198 | — | — | 1 | 6.85 |
| CHEMBL4214634 | — | — | 1 | 6.85 |
| CHEMBL4202432 | — | — | 1 | 6.85 |
| CHEMBL4216534 | — | — | 1 | 6.80 |
| CHEMBL4208504 | — | — | 1 | 6.68 |
| CHEMBL4214898 | — | — | 1 | 6.58 |
| CHEMBL4207218 | — | — | 1 | 6.50 |
| CHEMBL4205366 | — | — | 1 | 6.47 |
| CHEMBL4208875 | — | — | 1 | 6.34 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 6.34 |
| CHEMBL4214123 | — | — | 1 | 6.28 |
| CHEMBL4218705 | — | — | 1 | 6.28 |
| CHEMBL4211162 | — | — | 1 | 6.20 |
| CHEMBL4203994 | — | — | 1 | 5.82 |
| CHEMBL4213770 | — | — | 1 | 5.43 |
| CHEMBL4206797 | — | — | 1 | 5.25 |
| CHEMBL4206280 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4218267 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4204030 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4213557 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4208198 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4214634 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4202432 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4216534 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4208504 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4214898 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4207218 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4205366 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4208875 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4214123 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4218705 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4211162 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4203994 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4213770 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL4206797 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4206280 | — | IC50 | - | — | - |