Assay Detail
Functional
CHEMBL4180663
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of human CB1 receptor expressed in CHO-K1 cell membranes assessed as induction of [3H]CP55,940 binding after 1.5 hrs by liquid scintillation counting assay
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.18 | 7.37 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4215809 | — | — | 2 | 7.37 |
| CHEMBL3341861 | — | — | 1 | 6.57 |
| CHEMBL4206416 | — | — | 1 | 5.89 |
| CHEMBL4203175 | — | — | 1 | 4.87 |
| CHEMBL4210152 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4215809 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3341861 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4206416 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4203175 | — | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4215809 | — | Activity | - | — | - | |
| CHEMBL4210152 | — | EC50 | > | 10000.0 | nM | - |