Assay Detail
Functional
CHEMBL4180707
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Cytotoxicity against human NCI-H460 cells after 24 hrs under hypoxic condition by luminescence-based Cell-Titer Glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.89 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16932 | — | — | 1 | 10.21 |
| CHEMBL1165777 | — | — | 1 | 9.27 |
| CHEMBL4216973 | — | — | 1 | 8.96 |
| CHEMBL260046 | EVOFOSFAMIDE | 3.0 | 1 | 8.03 |
| CHEMBL4209698 | — | — | 1 | 7.77 |
| CHEMBL54905 | — | — | 1 | 6.56 |
| CHEMBL4209619 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16932 | — | IC50 | = | 0.062 | nM | 10.21 |
| CHEMBL1165777 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL4216973 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL260046 | EVOFOSFAMIDE | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL4209698 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL54905 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL4209619 | — | IC50 | = | 35000.0 | nM | 4.46 |