Assay Detail
ADMET
CHEMBL4180708
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Cytotoxicity against human NCI-H460 cells after 24 hrs under normoxic condition by luminescence-based Cell-Titer Glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.68 | 10.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16932 | — | — | 1 | 10.04 |
| CHEMBL1165777 | — | — | 1 | 9.11 |
| CHEMBL4216973 | — | — | 1 | 8.85 |
| CHEMBL4209698 | — | — | 1 | 6.63 |
| CHEMBL54905 | — | — | 1 | 6.26 |
| CHEMBL260046 | EVOFOSFAMIDE | 3.0 | 1 | 5.18 |
| CHEMBL4209619 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16932 | — | IC50 | = | 0.092 | nM | 10.04 |
| CHEMBL1165777 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL4216973 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4209698 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL54905 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL260046 | EVOFOSFAMIDE | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL4209619 | — | IC50 | = | 196000.0 | nM | - |