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Assay Detail

CHEMBL4180916

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-glycosylation activity using BSA assessed as inhibition of AGE formation measured after 30 hrs by fluorescence spectrophotometric method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Publication

Exploration of multi-target potential of chromen-4-one based compounds in Alzheimer's disease: Design, synthesis and biological evaluations.
Singh M, Kaur M, Singh N, Silakari O.
Bioorg Med Chem (2017) 25 : 6273 -6285
PubMed 29089261 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.33 4.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4217941 1 4.43
CHEMBL4218884 1 4.42
CHEMBL225304 PIMAGEDINE 2.0 1 4.40
CHEMBL4207594 1 4.38
CHEMBL16751 1 4.38
CHEMBL4213552 1 4.38
CHEMBL4204793 1 4.37
CHEMBL4214058 1 4.37
CHEMBL4208825 1 4.32
CHEMBL345778 1 4.32
CHEMBL4209658 1 4.32
CHEMBL4210581 1 4.31
CHEMBL4203490 1 4.30
CHEMBL485247 1 4.29
CHEMBL4218485 1 4.28
CHEMBL4207152 1 4.26
CHEMBL4205720 1 4.24
CHEMBL4216881 1 4.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4217941 IC50 = 37120.0 nM 4.43
CHEMBL4218884 IC50 = 38420.0 nM 4.42
CHEMBL225304 PIMAGEDINE IC50 = 40060.0 nM 4.40
CHEMBL4207594 IC50 = 41750.0 nM 4.38
CHEMBL16751 IC50 = 42000.0 nM 4.38
CHEMBL4213552 IC50 = 42100.0 nM 4.38
CHEMBL4204793 IC50 = 43150.0 nM 4.37
CHEMBL4214058 IC50 = 42600.0 nM 4.37
CHEMBL4208825 IC50 = 47700.0 nM 4.32
CHEMBL345778 IC50 = 47400.0 nM 4.32
CHEMBL4209658 IC50 = 48240.0 nM 4.32
CHEMBL4210581 IC50 = 49360.0 nM 4.31
CHEMBL4203490 IC50 = 50400.0 nM 4.30
CHEMBL485247 IC50 = 51400.0 nM 4.29
CHEMBL4218485 IC50 = 52700.0 nM 4.28
CHEMBL4207152 IC50 = 55120.0 nM 4.26
CHEMBL4205720 IC50 = 57230.0 nM 4.24
CHEMBL4216881 IC50 = 61640.0 nM 4.21