Assay Detail
Binding
CHEMBL4181121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTORC2 in human HeLa cells assessed as decrease in AKT phosphorylation at S473 residue preincubated for 1 hr followed by EGF1 stimulation by ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, antifungal and antitumor activity of two new types of imidazolin-2-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.60 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 7.64 |
| CHEMBL4212680 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1079175 | MK-2206 | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL4212680 | — | IC50 | = | 2790.0 | nM | 5.55 |