Assay Detail
Binding
CHEMBL4181319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of sodium channel in human SK-N-SH cells assessed as reduction in veratridine-induced [22Na] uptake by scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-SH |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.74 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4206581 | — | — | 1 | 5.85 |
| CHEMBL3931344 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4206581 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3931344 | — | IC50 | = | 2400.0 | nM | 5.62 |