Assay Detail
Functional
CHEMBL4181452
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Antiproliferative activity against human NCI-H226 cells after 72 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H226 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.69 | 10.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205723 | — | — | 1 | 10.62 |
| CHEMBL4213013 | — | — | 1 | 10.33 |
| CHEMBL4214485 | — | — | 1 | 9.93 |
| CHEMBL4217429 | — | — | 1 | 9.45 |
| CHEMBL4218141 | — | — | 1 | 9.18 |
| CHEMBL4209576 | — | — | 1 | 9.00 |
| CHEMBL4217945 | — | — | 1 | 8.97 |
| CHEMBL4212187 | — | — | 1 | 8.80 |
| CHEMBL4202522 | — | — | 1 | 8.09 |
| CHEMBL4202586 | — | — | 1 | 8.06 |
| CHEMBL4207470 | — | — | 1 | 7.92 |
| CHEMBL279754 | DSB-120 | — | 1 | 7.16 |
| CHEMBL4210094 | — | — | 1 | 7.16 |
| CHEMBL4205196 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205723 | — | IC50 | = | 0.024 | nM | 10.62 |
| CHEMBL4213013 | — | IC50 | = | 0.047 | nM | 10.33 |
| CHEMBL4214485 | — | IC50 | = | 0.117 | nM | 9.93 |
| CHEMBL4217429 | — | IC50 | = | 0.355 | nM | 9.45 |
| CHEMBL4218141 | — | IC50 | = | 0.655 | nM | 9.18 |
| CHEMBL4209576 | — | IC50 | = | 0.993 | nM | 9.00 |
| CHEMBL4217945 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL4212187 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4202522 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4202586 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4207470 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL279754 | DSB-120 | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4210094 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4205196 | — | IC50 | = | 109.0 | nM | 6.96 |