Assay Detail
Functional
CHEMBL4181682
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Antimalarial activity against mid-ring stage of multidrug-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.14 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.39 |
| CHEMBL4209486 | — | — | 1 | 7.28 |
| CHEMBL4218177 | — | — | 1 | 7.22 |
| CHEMBL4207961 | — | — | 1 | 7.11 |
| CHEMBL4213904 | — | — | 1 | 6.98 |
| CHEMBL4203015 | — | — | 1 | 6.57 |
| CHEMBL4218788 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4209486 | — | IC50 | = | 53.1 | nM | 7.28 |
| CHEMBL4218177 | — | IC50 | = | 60.5 | nM | 7.22 |
| CHEMBL4207961 | — | IC50 | = | 78.6 | nM | 7.11 |
| CHEMBL4213904 | — | IC50 | = | 105.1 | nM | 6.98 |
| CHEMBL4203015 | — | IC50 | = | 266.4 | nM | 6.57 |
| CHEMBL4218788 | — | IC50 | = | 390.9 | nM | 6.41 |