Assay Detail
Functional
CHEMBL4181685
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Antimalarial activity against mid-ring stage of chloroquine-resistant Plasmodium falciparum Dd2 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.79 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4209486 | — | — | 1 | 5.92 |
| CHEMBL4218177 | — | — | 1 | 5.66 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4209486 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4218177 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | > | 10000.0 | nM | - |