Assay Detail
Functional
CHEMBL4181985
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 46 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Imidazo[1,2-a]pyridines linked with thiazoles/thiophene motif through keto spacer as potential cytotoxic agents and NF-κB inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.69 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.13 |
| CHEMBL4215065 | — | — | 1 | 4.83 |
| CHEMBL4214832 | — | — | 1 | 4.73 |
| CHEMBL4207217 | — | — | 1 | 4.65 |
| CHEMBL4212097 | — | — | 1 | 4.64 |
| CHEMBL4205768 | — | — | 1 | 4.25 |
| CHEMBL4202872 | — | — | 1 | 4.25 |
| CHEMBL4213059 | — | — | 1 | 4.07 |
| CHEMBL4217984 | — | — | 1 | - |
| CHEMBL4211161 | — | — | 1 | - |
| CHEMBL4206279 | — | — | 1 | - |
| CHEMBL4203396 | — | — | 1 | - |
| CHEMBL4204226 | — | — | 1 | - |
| CHEMBL4211571 | — | — | 1 | - |
| CHEMBL4203183 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4215065 | — | IC50 | = | 14710.0 | nM | 4.83 |
| CHEMBL4214832 | — | IC50 | = | 18580.0 | nM | 4.73 |
| CHEMBL4207217 | — | IC50 | = | 22460.0 | nM | 4.65 |
| CHEMBL4212097 | — | IC50 | = | 22760.0 | nM | 4.64 |
| CHEMBL4205768 | — | IC50 | = | 56910.0 | nM | 4.25 |
| CHEMBL4202872 | — | IC50 | = | 56880.0 | nM | 4.25 |
| CHEMBL4213059 | — | IC50 | = | 85250.0 | nM | 4.07 |
| CHEMBL4217984 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4211161 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4206279 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4203396 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4204226 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4211571 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4203183 | — | IC50 | > | 100000.0 | nM | - |