Assay Detail
Binding
CHEMBL4181992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NF-kappaB (unknown origin) expressed in human A431 cells using p-NPP as substrate incubated for 48 hrs followed by substrate addition measured after 1 hr by SEAP reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Imidazo[1,2-a]pyridines linked with thiazoles/thiophene motif through keto spacer as potential cytotoxic agents and NF-κB inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.04 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186141 | ANDROGRAPHOLIDE | 3.0 | 1 | 5.64 |
| CHEMBL4202872 | — | — | 1 | 5.19 |
| CHEMBL4211571 | — | — | 1 | 5.14 |
| CHEMBL4212097 | — | — | 1 | 5.09 |
| CHEMBL4215065 | — | — | 1 | 5.05 |
| CHEMBL4214832 | — | — | 1 | 4.98 |
| CHEMBL4207217 | — | — | 1 | 4.21 |
| CHEMBL4203396 | — | — | 1 | - |
| CHEMBL4206279 | — | — | 1 | - |
| CHEMBL4211161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186141 | ANDROGRAPHOLIDE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4202872 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4211571 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4212097 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4215065 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4214832 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4207217 | — | IC50 | = | 61200.0 | nM | 4.21 |
| CHEMBL4203396 | — | IC50 | = | 184580.0 | nM | - |
| CHEMBL4206279 | — | IC50 | = | 187620.0 | nM | - |
| CHEMBL4211161 | — | IC50 | = | 185010.0 | nM | - |