Assay Detail
Functional
CHEMBL4182264
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Cytotoxicity against human HD-MB03 cells assessed as reduction in cell viability after 5 days by CellTiter-Glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.43 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957266 | — | — | 1 | 6.80 |
| CHEMBL4209110 | — | — | 1 | 6.77 |
| CHEMBL2177300 | — | — | 1 | 6.70 |
| CHEMBL1232461 | MOLIBRESIB | 2.0 | 1 | 5.46 |
| CHEMBL2393130 | APABETALONE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957266 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4209110 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2177300 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1232461 | MOLIBRESIB | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2393130 | APABETALONE | EC50 | > | 5000.0 | nM | - |