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Assay Detail

CHEMBL4182482

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Functional
Antiparasitic activity against Leishmania infantum
22
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania infantum
Confidence 1 — Organism
Curated By Intermediate

Target

Leishmania infantum (CHEMBL612848)
Type ORGANISM
Organism Leishmania infantum

Publication

Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Thompson AM, Marshall AJ, Maes L, Yarlett N, Bacchi CJ, Gaukel E, Wring SA, Launay D, Braillard S, Chatelain E, Mowbray CE, Denny WA.
Bioorg Med Chem Lett (2018) 28 : 207 -213
PubMed 29191556 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.92 6.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4218022 2 6.39
CHEMBL480726 1 5.47
CHEMBL4203611 2 5.16
CHEMBL4212632 1 5.16
CHEMBL481740 1 5.14
CHEMBL4216414 1 5.12
CHEMBL4211008 1 5.00
CHEMBL4217401 1 5.00
CHEMBL4211049 2 4.89
CHEMBL480569 2 4.80
CHEMBL4208438 1 4.52
CHEMBL4216446 1 4.50
CHEMBL4206242 1 4.39
CHEMBL480728 1 4.35
CHEMBL4215751 1 4.32
CHEMBL480559 1 4.26
CHEMBL480727 1 -
CHEMBL4204439 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4218022 IC50 = 410.0 nM 6.39
CHEMBL4218022 IC50 = 2000.0 nM 5.70
CHEMBL480726 IC50 = 3400.0 nM 5.47
CHEMBL4212632 IC50 = 7000.0 nM 5.16
CHEMBL4203611 IC50 = 7000.0 nM 5.16
CHEMBL481740 IC50 = 7300.0 nM 5.14
CHEMBL4216414 IC50 = 7500.0 nM 5.12
CHEMBL4217401 IC50 = 10000.0 nM 5.00
CHEMBL4211008 IC50 = 10000.0 nM 5.00
CHEMBL4211049 IC50 = 13000.0 nM 4.89
CHEMBL480569 IC50 = 16000.0 nM 4.80
CHEMBL4208438 IC50 = 30000.0 nM 4.52
CHEMBL4216446 IC50 = 32000.0 nM 4.50
CHEMBL4206242 IC50 = 41000.0 nM 4.39
CHEMBL4211049 IC50 = 41000.0 nM 4.39
CHEMBL480728 IC50 = 45000.0 nM 4.35
CHEMBL4215751 IC50 = 48000.0 nM 4.32
CHEMBL480559 IC50 = 55000.0 nM 4.26
CHEMBL480727 IC50 > 64000.0 nM -
CHEMBL4203611 IC50 > 64000.0 nM -
CHEMBL480569 IC50 > 64000.0 nM -
CHEMBL4204439 IC50 > 64000.0 nM -