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Assay Detail

CHEMBL4182541

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitumor activity against mouse B16F10 cells incubated for 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type B16-F10
Confidence 1 — Organism
Curated By Intermediate

Target

B16-F10 (CHEMBL612656)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis, antitumor activity, and cytotoxicity of 4-substituted 1-benzyl-5-diphenylstibano-1H-1,2,3-triazoles.
Yamada M, Takahashi T, Hasegawa M, Matsumura M, Ono K, Fujimoto R, Kitamura Y, Murata Y, Kakusawa N, Tanaka M, Obata T, Fujiwara Y, Yasuike S.
Bioorg Med Chem Lett (2018) 28 : 152 -154
PubMed 29198863 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.35 6.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4218515 1 6.50
CHEMBL4213943 1 6.47
CHEMBL4212767 1 6.41
CHEMBL4215752 1 6.36
CHEMBL4215199 1 6.33
CHEMBL4217050 1 5.79
CHEMBL3984629 1 4.45
CHEMBL4218463 1 4.34
CHEMBL3987171 1 4.18
CHEMBL3960705 1 4.05
CHEMBL1825043 1 4.02
CHEMBL4216437 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4218515 IC50 = 320.0 nM 6.50
CHEMBL4213943 IC50 = 340.0 nM 6.47
CHEMBL4212767 IC50 = 390.0 nM 6.41
CHEMBL4215752 IC50 = 440.0 nM 6.36
CHEMBL4215199 IC50 = 470.0 nM 6.33
CHEMBL4217050 IC50 = 1610.0 nM 5.79
CHEMBL3984629 IC50 = 35400.0 nM 4.45
CHEMBL4218463 IC50 = 45500.0 nM 4.34
CHEMBL3987171 IC50 = 66400.0 nM 4.18
CHEMBL3960705 IC50 = 88500.0 nM 4.05
CHEMBL1825043 IC50 = 96100.0 nM 4.02
CHEMBL4216437 IC50 = 421000.0 nM -