Assay Detail
Binding
CHEMBL4182592
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Inactivation of Bacillus anthracis edema factor in mouse RAW264.7 cells assessed as reduction in cAMP production using cells exposed to edema factor for 30 mins before compound addition for 45 mins by immunoassay
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule inhibitors of anthrax edema factor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.45 | 7.92 |
| Inhibition | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4218073 | — | — | 2 | 7.92 |
| CHEMBL4217380 | — | — | 2 | 7.62 |
| CHEMBL4204554 | — | — | 2 | 7.50 |
| CHEMBL4211713 | — | — | 2 | 7.22 |
| CHEMBL4218072 | — | — | 2 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4218073 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4217380 | — | EC50 | = | 23.7 | nM | 7.62 |
| CHEMBL4204554 | — | EC50 | = | 31.7 | nM | 7.50 |
| CHEMBL4211713 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4218072 | — | EC50 | = | 104.6 | nM | 6.98 |
| CHEMBL4211713 | — | Inhibition | - | % | - | |
| CHEMBL4218072 | — | Inhibition | - | % | - | |
| CHEMBL4217380 | — | Inhibition | - | % | - | |
| CHEMBL4218073 | — | Inhibition | - | % | - | |
| CHEMBL4204554 | — | Inhibition | - | % | - |