Assay Detail
Binding
CHEMBL4182824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Bax-derived peptide from Bcl-2 (unknown origin) by fluorescence polarization assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.36 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | 8.13 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.99 |
| CHEMBL4216466 | — | — | 1 | 7.90 |
| CHEMBL4207006 | — | — | 1 | 7.84 |
| CHEMBL4211198 | — | — | 1 | 7.76 |
| CHEMBL4206829 | — | — | 1 | 7.68 |
| CHEMBL4202464 | — | — | 1 | 7.46 |
| CHEMBL4216380 | — | — | 1 | 7.42 |
| CHEMBL4209752 | — | — | 1 | 7.39 |
| CHEMBL4209621 | — | — | 1 | 7.34 |
| CHEMBL4206007 | — | — | 1 | 7.33 |
| CHEMBL4211496 | — | — | 1 | 7.24 |
| CHEMBL4210809 | — | — | 1 | 7.19 |
| CHEMBL4208633 | — | — | 1 | 7.17 |
| CHEMBL4218253 | — | — | 1 | 7.17 |
| CHEMBL4218405 | — | — | 1 | 6.97 |
| CHEMBL4213316 | — | — | 1 | 6.78 |
| CHEMBL4215940 | — | — | 1 | 6.71 |
| CHEMBL4204650 | — | — | 1 | 6.30 |
| CHEMBL4204583 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137309 | VENETOCLAX | IC50 | = | 7.39 | nM | 8.13 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL4216466 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL4207006 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL4211198 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL4206829 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL4202464 | — | IC50 | = | 34.8 | nM | 7.46 |
| CHEMBL4216380 | — | IC50 | = | 38.1 | nM | 7.42 |
| CHEMBL4209752 | — | IC50 | = | 40.7 | nM | 7.39 |
| CHEMBL4209621 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4206007 | — | IC50 | = | 46.6 | nM | 7.33 |
| CHEMBL4211496 | — | IC50 | = | 57.9 | nM | 7.24 |
| CHEMBL4210809 | — | IC50 | = | 65.1 | nM | 7.19 |
| CHEMBL4208633 | — | IC50 | = | 68.2 | nM | 7.17 |
| CHEMBL4218253 | — | IC50 | = | 67.4 | nM | 7.17 |
| CHEMBL4218405 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4213316 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL4215940 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL4204650 | — | IC50 | = | 495.0 | nM | 6.30 |
| CHEMBL4204583 | — | IC50 | > | 1000.0 | nM | - |