Assay Detail
Binding
CHEMBL4182987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(+)-MK-801 from PCP binding site of NMDA receptor in pig brain cortex membranes after 150 mins by solid scintillation counting
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.82 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1165411 | DEXOXADROL | 2.0 | 1 | 7.50 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1165411 | DEXOXADROL | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL807 | MEMANTINE | Ki | = | 740.0 | nM | 6.13 |