Assay Detail
ADMET
CHEMBL4183115
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Inhibition of Cathepsin D (unknown origin) by fluorescence polarization assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.46 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3983988 | — | — | 1 | 4.46 |
| CHEMBL3922902 | — | — | 1 | - |
| CHEMBL4203860 | — | — | 1 | - |
| CHEMBL4215837 | — | — | 1 | - |
| CHEMBL4204163 | — | — | 1 | - |
| CHEMBL3941301 | — | — | 1 | - |
| CHEMBL3972449 | — | — | 1 | - |
| CHEMBL3952064 | — | — | 1 | - |
| CHEMBL4211913 | — | — | 1 | - |
| CHEMBL3947194 | — | — | 1 | - |
| CHEMBL3967984 | — | — | 1 | - |
| CHEMBL3917530 | — | — | 1 | - |
| CHEMBL3979124 | — | — | 1 | - |
| CHEMBL4217023 | — | — | 1 | - |
| CHEMBL4214785 | — | — | 1 | - |
| CHEMBL4204215 | — | — | 1 | - |
| CHEMBL4203347 | — | — | 1 | - |
| CHEMBL4214603 | — | — | 1 | - |
| CHEMBL4209354 | — | — | 1 | - |
| CHEMBL4207711 | — | — | 1 | - |
| CHEMBL4209994 | — | — | 1 | - |
| CHEMBL4212046 | — | — | 1 | - |
| CHEMBL3414707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3983988 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL3922902 | — | IC50 | > | 95000.0 | nM | - |
| CHEMBL4203860 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4215837 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL4204163 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3941301 | — | IC50 | > | 96700.0 | nM | - |
| CHEMBL3972449 | — | IC50 | > | 70300.0 | nM | - |
| CHEMBL3952064 | — | IC50 | > | 95300.0 | nM | - |
| CHEMBL4211913 | — | IC50 | = | 197600.0 | nM | - |
| CHEMBL3947194 | — | IC50 | = | 163600.0 | nM | - |
| CHEMBL3967984 | — | IC50 | > | 97000.0 | nM | - |
| CHEMBL3917530 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3979124 | — | IC50 | > | 43000.0 | nM | - |
| CHEMBL4217023 | — | IC50 | > | 97000.0 | nM | - |
| CHEMBL4214785 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4204215 | — | IC50 | > | 98000.0 | nM | - |
| CHEMBL4203347 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4214603 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4209354 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4207711 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4209994 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4212046 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3414707 | — | IC50 | > | 72000.0 | nM | - |