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Assay Detail

CHEMBL4183225

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat small intestinal mucosal alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate after 40 mins by colorimetric method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo.
Wang K, Bao L, Zhou N, Zhang J, Liao M, Zheng Z, Wang Y, Liu C, Wang J, Wang L, Wang W, Liu S, Liu H.
J Med Chem (2018) 61 : 3609 -3625
PubMed 29634260 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.74 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4204041 1 7.22
CHEMBL4202495 1 6.77
CHEMBL4216284 1 6.58
CHEMBL4210421 1 6.54
CHEMBL4096720 1 6.42
CHEMBL4216288 1 5.91
CHEMBL404271 ACARBOSE 4.0 1 5.90
CHEMBL4213110 1 5.80
CHEMBL4216783 1 5.69
CHEMBL4215012 1 5.64
CHEMBL4209384 1 5.29
CHEMBL4211834 1 5.22
CHEMBL4213527 1 4.92
CHEMBL4204038 1 4.71
CHEMBL4206214 1 4.66
CHEMBL4217384 1 4.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4204041 IC50 = 60.0 nM 7.22
CHEMBL4202495 IC50 = 170.0 nM 6.77
CHEMBL4216284 IC50 = 260.0 nM 6.58
CHEMBL4210421 IC50 = 290.0 nM 6.54
CHEMBL4096720 IC50 = 380.0 nM 6.42
CHEMBL4216288 IC50 = 1240.0 nM 5.91
CHEMBL404271 ACARBOSE IC50 = 1260.0 nM 5.90
CHEMBL4213110 IC50 = 1590.0 nM 5.80
CHEMBL4216783 IC50 = 2040.0 nM 5.69
CHEMBL4215012 IC50 = 2270.0 nM 5.64
CHEMBL4209384 IC50 = 5110.0 nM 5.29
CHEMBL4211834 IC50 = 5980.0 nM 5.22
CHEMBL4213527 IC50 = 12120.0 nM 4.92
CHEMBL4204038 IC50 = 19280.0 nM 4.71
CHEMBL4206214 IC50 = 21710.0 nM 4.66
CHEMBL4217384 IC50 = 32760.0 nM 4.49