Assay Detail
Binding
CHEMBL4183226
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat small intestinal mucosal alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by HPLC method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.35 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204041 | — | — | 1 | 7.40 |
| CHEMBL4202495 | — | — | 1 | 6.80 |
| CHEMBL4210421 | — | — | 1 | 6.64 |
| CHEMBL4217384 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204041 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4202495 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4210421 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4217384 | — | IC50 | = | 28660.0 | nM | 4.54 |