Assay Detail
Binding
CHEMBL4184343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.73 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217261 | — | — | 1 | 6.14 |
| CHEMBL4205708 | — | — | 1 | 5.93 |
| CHEMBL4209443 | — | — | 1 | 5.48 |
| CHEMBL4215300 | — | — | 1 | 5.38 |
| CHEMBL4210359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217261 | — | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL4205708 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4209443 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL4215300 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL4210359 | — | IC50 | > | 30000.0 | nM | - |