Assay Detail
Binding
CHEMBL4184688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav1.5 channel expressed in HEK293 cells at holding potential of -70 mV by whole cell patch clamp assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 5 subunit alpha (CHEMBL1980) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K+ channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.47 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL841 | LOPERAMIDE | 4.0 | 1 | 6.62 |
| CHEMBL1627 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL841 | LOPERAMIDE | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL1627 | — | IC50 | = | 483.0 | nM | 6.32 |