Assay Detail
Functional
CHEMBL4184877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human COR-L23 cells after 4 days by CellTiter-Glo assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COR-L23 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.31 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4203945 | — | — | 1 | 8.40 |
| CHEMBL4212358 | — | — | 1 | 8.22 |
| CHEMBL4204004 | — | — | 1 | 8.15 |
| CHEMBL4209341 | — | — | 1 | 8.10 |
| CHEMBL4209447 | — | — | 1 | 8.10 |
| CHEMBL4208619 | — | — | 1 | 7.96 |
| CHEMBL4207982 | — | — | 1 | 7.92 |
| CHEMBL4213810 | — | — | 1 | 7.77 |
| CHEMBL4217456 | — | — | 1 | 7.75 |
| CHEMBL4211212 | — | — | 1 | 7.72 |
| CHEMBL4215840 | — | — | 1 | 7.66 |
| CHEMBL4205098 | — | — | 1 | 7.46 |
| CHEMBL4204746 | — | — | 1 | 7.34 |
| CHEMBL4213004 | — | — | 1 | 7.24 |
| CHEMBL4217940 | — | — | 1 | 7.11 |
| CHEMBL4202544 | — | — | 1 | 7.04 |
| CHEMBL4210641 | — | — | 1 | 6.96 |
| CHEMBL4211401 | — | — | 1 | 6.86 |
| CHEMBL4209227 | — | — | 1 | 6.86 |
| CHEMBL4206515 | — | — | 1 | 6.20 |
| CHEMBL4216041 | — | — | 1 | 5.88 |
| CHEMBL4211993 | — | — | 1 | 5.70 |
| CHEMBL4210883 | — | — | 1 | 5.64 |
| CHEMBL4210753 | — | — | 1 | - |
| CHEMBL4215893 | — | — | 1 | - |
| CHEMBL4215088 | — | — | 1 | - |
| CHEMBL4206641 | — | — | 1 | - |
| CHEMBL4214006 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4203945 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4212358 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4204004 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4209341 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4209447 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4208619 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4207982 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4213810 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4217456 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4211212 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4215840 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4205098 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4204746 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4213004 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4217940 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4202544 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4210641 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4211401 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL4209227 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL4206515 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4216041 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4211993 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4210883 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4210753 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL4215893 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4215088 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4206641 | — | IC50 | - | — | - | |
| CHEMBL4214006 | — | IC50 | > | 2500.0 | nM | - |