Assay Detail
ADMET
CHEMBL4184977
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Growth inhibition of human MRC5 cells after 7 days by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca<sup>2+</sup> pump inhibitor from marine cyanobacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.76 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216774 | — | — | 1 | 6.64 |
| CHEMBL4207081 | — | — | 1 | 6.40 |
| CHEMBL4208885 | — | — | 1 | 5.54 |
| CHEMBL4205962 | — | — | 1 | 5.52 |
| CHEMBL4218640 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216774 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4207081 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4208885 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4205962 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4218640 | — | IC50 | = | 19000.0 | nM | 4.72 |