Assay Detail
Functional
CHEMBL4184979
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human type A+ erythrocytes assessed as growth inhibition after 72 hrs by LDH assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca<sup>2+</sup> pump inhibitor from marine cyanobacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.90 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4207081 | — | — | 1 | 5.47 |
| CHEMBL4208885 | — | — | 1 | 4.80 |
| CHEMBL4205962 | — | — | 1 | 4.72 |
| CHEMBL4216774 | — | — | 1 | 4.62 |
| CHEMBL4218640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4207081 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4208885 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4205962 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4216774 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4218640 | — | IC50 | > | 31000.0 | nM | - |