Assay Detail
Functional
CHEMBL4185016
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Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Target ROS to induce apoptosis and cell cycle arrest by 5,7-dimethoxy-1,4-naphthoquinone derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.27 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208719 | — | — | 1 | 4.64 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.44 |
| CHEMBL4213121 | — | — | 1 | 4.43 |
| CHEMBL4203196 | — | — | 1 | 4.43 |
| CHEMBL4218044 | — | — | 1 | 4.38 |
| CHEMBL4213659 | — | — | 1 | 4.32 |
| CHEMBL4209903 | — | — | 1 | 4.30 |
| CHEMBL4210196 | — | — | 1 | 4.25 |
| CHEMBL4207407 | — | — | 1 | 4.22 |
| CHEMBL4206301 | — | — | 1 | 4.13 |
| CHEMBL4217536 | — | — | 1 | 4.09 |
| CHEMBL4212647 | — | — | 1 | 4.04 |
| CHEMBL4203078 | — | — | 1 | 4.02 |
| CHEMBL4213797 | — | — | 1 | 4.02 |
| CHEMBL4206970 | — | — | 1 | - |
| CHEMBL4214301 | — | — | 1 | - |
| CHEMBL4205029 | — | — | 1 | - |
| CHEMBL4206464 | — | — | 1 | - |
| CHEMBL4218195 | — | — | 1 | - |
| CHEMBL4210765 | — | — | 1 | - |
| CHEMBL4215721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208719 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL4213121 | — | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL4203196 | — | IC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL4218044 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL4213659 | — | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL4209903 | — | IC50 | = | 49900.0 | nM | 4.30 |
| CHEMBL4210196 | — | IC50 | = | 55900.0 | nM | 4.25 |
| CHEMBL4207407 | — | IC50 | = | 60700.0 | nM | 4.22 |
| CHEMBL4206301 | — | IC50 | = | 73200.0 | nM | 4.13 |
| CHEMBL4217536 | — | IC50 | = | 81400.0 | nM | 4.09 |
| CHEMBL4212647 | — | IC50 | = | 90400.0 | nM | 4.04 |
| CHEMBL4203078 | — | IC50 | = | 95700.0 | nM | 4.02 |
| CHEMBL4213797 | — | IC50 | = | 95900.0 | nM | 4.02 |
| CHEMBL4206970 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4214301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4205029 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4206464 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4218195 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4210765 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4215721 | — | IC50 | > | 100000.0 | nM | - |