Assay Detail
Functional
CHEMBL4185133
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Antiproliferative activity against human Mahlavu cells after 72 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Mahlavu |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of novel 6-substituted amino-9-(β-d-ribofuranosyl)purine analogs and their bioactivities on human epithelial cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.14 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 7.00 |
| CHEMBL4205001 | — | — | 1 | 5.52 |
| CHEMBL4207388 | — | — | 1 | 5.16 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 5.00 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.00 |
| CHEMBL4212800 | — | — | 1 | 4.52 |
| CHEMBL4211749 | — | — | 1 | 4.52 |
| CHEMBL4208991 | — | — | 1 | 4.40 |
| CHEMBL4214682 | — | — | 1 | - |
| CHEMBL4215665 | — | — | 1 | - |
| CHEMBL4211232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4205001 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4207388 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4212800 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4211749 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4208991 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4214682 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4215665 | — | IC50 | - | — | - | |
| CHEMBL4211232 | — | IC50 | > | 100000.0 | nM | - |