Assay Detail
Binding
CHEMBL4185149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human APE1 using a 5'-TAMRA labelled THF abasic site double-stranded oligodeoxynucleotide as substrate in presence of Mg2+ by fluorescence polarization displacement assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA repair nuclease/redox regulator APEX1 (CHEMBL5619) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.73 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1346456 | — | — | 1 | 6.40 |
| CHEMBL1601846 | — | — | 1 | 6.40 |
| CHEMBL1597042 | — | — | 1 | 5.55 |
| CHEMBL1497243 | — | — | 1 | 5.17 |
| CHEMBL1541779 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1346456 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1601846 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1597042 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1497243 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1541779 | — | IC50 | = | 7070.0 | nM | 5.15 |