Assay Detail
Binding
CHEMBL4185229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His6-tagged recombinant Leishmania infantum SIR2RP1 expressed in Escherichia coli in presence of NAD+ by fluorimetric method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania infantum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Putative silent information regulator 2 (CHEMBL2311240) ↗| Type | SINGLE PROTEIN |
| Organism | Leishmania infantum |
Publication
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.18 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216559 | — | — | 1 | 5.24 |
| CHEMBL4211052 | — | — | 1 | 5.24 |
| CHEMBL4204117 | — | — | 1 | 5.24 |
| CHEMBL4215363 | — | — | 1 | 5.24 |
| CHEMBL4206570 | — | — | 1 | 5.24 |
| CHEMBL4211460 | — | — | 1 | 5.24 |
| CHEMBL4214749 | — | — | 1 | 5.24 |
| CHEMBL4209842 | — | — | 1 | 5.24 |
| CHEMBL4217062 | — | — | 1 | 5.24 |
| CHEMBL4205463 | — | — | 1 | 5.24 |
| CHEMBL4205986 | — | — | 1 | 5.24 |
| CHEMBL4217704 | — | — | 1 | 5.24 |
| CHEMBL4218232 | — | — | 1 | 5.24 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 5.16 |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | 4.40 |
| CHEMBL380797 | SIRTINOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216559 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4211052 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4204117 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4215363 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4206570 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4211460 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4214749 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4209842 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4217062 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4205463 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4205986 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4217704 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4218232 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL265502 | SURAMIN | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 194000.0 | nM | - |