Assay Detail
Binding
CHEMBL4185230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SIRT1 in presence of NAD+ by fluorimetric method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.01 | 4.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216559 | — | — | 1 | 4.01 |
| CHEMBL380797 | SIRTINOL | — | 1 | - |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216559 | — | IC50 | = | 97400.0 | nM | 4.01 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 245000.0 | nM | - |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 118000.0 | nM | - |