Assay Detail
Functional
CHEMBL4185233
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Antileishmanial activity against amastigote stage of Leishmania infantum MHOM/MA671TMAP263 expressing luciferase after 72 hrs by luciferase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.87 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216559 | — | — | 1 | 5.22 |
| CHEMBL380797 | SIRTINOL | — | 1 | 4.52 |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | - |
| CHEMBL1322831 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216559 | — | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 5500000.0 | nM | - |
| CHEMBL1322831 | — | IC50 | = | 1490000.0 | nM | - |