Assay Detail
Functional
CHEMBL4185404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.24 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164015 | — | — | 1 | 8.70 |
| CHEMBL4214978 | — | — | 1 | 8.29 |
| CHEMBL4215403 | — | — | 1 | 8.22 |
| CHEMBL4208405 | — | — | 1 | 8.18 |
| CHEMBL4210062 | — | — | 1 | 7.89 |
| CHEMBL4211972 | — | — | 1 | 7.89 |
| CHEMBL4212515 | — | — | 1 | 7.82 |
| CHEMBL4203276 | — | — | 1 | 7.77 |
| CHEMBL3581661 | — | — | 1 | 7.70 |
| CHEMBL1957266 | — | — | 1 | 7.62 |
| CHEMBL4171228 | — | — | 1 | 7.58 |
| CHEMBL4208561 | — | — | 1 | 7.55 |
| CHEMBL4207609 | — | — | 1 | 7.54 |
| CHEMBL4210754 | — | — | 1 | 7.33 |
| CHEMBL4209113 | — | — | 1 | 7.24 |
| CHEMBL4218757 | — | — | 1 | 7.16 |
| CHEMBL4211497 | — | — | 1 | 7.12 |
| CHEMBL4207024 | — | — | 1 | 7.11 |
| CHEMBL1232461 | MOLIBRESIB | 2.0 | 1 | 7.03 |
| CHEMBL4203725 | — | — | 1 | 7.02 |
| CHEMBL4210981 | — | — | 1 | 7.00 |
| CHEMBL4213494 | — | — | 1 | 7.00 |
| CHEMBL2017291 | — | — | 1 | 6.79 |
| CHEMBL4215941 | — | — | 1 | 6.74 |
| CHEMBL4218866 | — | — | 1 | 6.72 |
| CHEMBL4207729 | — | — | 1 | 6.60 |
| CHEMBL4209937 | — | — | 1 | 6.53 |
| CHEMBL4205577 | — | — | 1 | 6.48 |
| CHEMBL4202675 | — | — | 1 | 6.37 |
| CHEMBL4212636 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164015 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4214978 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4215403 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4208405 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4210062 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4211972 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4212515 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4203276 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3581661 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1957266 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4171228 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4208561 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4207609 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4210754 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4209113 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4218757 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4211497 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4207024 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1232461 | MOLIBRESIB | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4203725 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4210981 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4213494 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2017291 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4215941 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL4218866 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4207729 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL4209937 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL4205577 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL4202675 | — | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL4212636 | — | IC50 | = | 1062.0 | nM | 5.97 |
| CHEMBL4217058 | — | IC50 | = | 2863.0 | nM | 5.54 |
| CHEMBL4216942 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4215450 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4210448 | — | IC50 | > | 1000.0 | nM | - |