Assay Detail
Binding
CHEMBL4185534
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Aspergillus fumigatus NMT (Gln86 to Leu492 residues) expressed in Escherichia coli BL21(DE3) pLysS cells using [3H]-myristoyl coenzyme A/CAP5.5 as substrate after 20 mins by scintillation proximity assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aspergillus fumigatus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glycylpeptide N-tetradecanoyltransferase (CHEMBL3988591) ↗| Type | SINGLE PROTEIN |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSCA1100) (Aspergillus fumigatus) |
Publication
Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.92 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3357685 | ZELENIRSTAT | 2.0 | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3357685 | ZELENIRSTAT | IC50 | = | 12.0 | nM | 7.92 |