Assay Detail
Binding
CHEMBL4186385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.42 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217213 | — | — | 1 | 9.05 |
| CHEMBL4208820 | — | — | 1 | 8.92 |
| CHEMBL4203082 | — | — | 1 | 8.92 |
| CHEMBL4204065 | — | — | 1 | 8.62 |
| CHEMBL4207965 | — | — | 1 | 8.55 |
| CHEMBL4204490 | — | — | 1 | 8.48 |
| CHEMBL4209361 | — | — | 1 | 8.48 |
| CHEMBL4215166 | — | — | 1 | 7.89 |
| CHEMBL4209359 | — | — | 1 | 7.64 |
| CHEMBL4214979 | — | — | 1 | 7.62 |
| CHEMBL4217552 | — | — | 1 | 7.57 |
| CHEMBL4218138 | — | — | 1 | 7.52 |
| CHEMBL4207043 | — | — | 1 | 7.51 |
| CHEMBL4209747 | — | — | 1 | 7.51 |
| CHEMBL4213692 | — | — | 1 | 7.42 |
| CHEMBL4208936 | — | — | 1 | 7.38 |
| CHEMBL4207080 | — | — | 1 | 7.37 |
| CHEMBL4203862 | — | — | 1 | 7.24 |
| CHEMBL4214660 | — | — | 1 | 7.19 |
| CHEMBL4210701 | — | — | 1 | 7.16 |
| CHEMBL4215815 | — | — | 1 | 7.16 |
| CHEMBL4218809 | — | — | 1 | 7.10 |
| CHEMBL4204263 | — | — | 1 | 7.09 |
| CHEMBL4210047 | — | — | 1 | 7.09 |
| CHEMBL4214949 | — | — | 1 | 7.05 |
| CHEMBL4203693 | — | — | 1 | 7.05 |
| CHEMBL4210763 | — | — | 1 | 6.92 |
| CHEMBL4206026 | — | — | 1 | 6.89 |
| CHEMBL4215879 | — | — | 1 | 6.82 |
| CHEMBL4207560 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217213 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4208820 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4203082 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4204065 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4207965 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4204490 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4209361 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4215166 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4209359 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4214979 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4217552 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4218138 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4207043 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4209747 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4213692 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4208936 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4207080 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4203862 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4214660 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4215815 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4210701 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4218809 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4204263 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4210047 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4214949 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4203693 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4210763 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4206026 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4215879 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4207560 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4215949 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4202407 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4216533 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4210092 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4217633 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3959584 | — | IC50 | = | 740.0 | nM | 6.13 |