Assay Detail
Functional
CHEMBL4186526
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Agonist activity at recombinant human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of a potent, well-balanced EP2/EP3 dual agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.41 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217198 | — | — | 1 | 7.58 |
| CHEMBL4206444 | — | — | 1 | 7.04 |
| CHEMBL4212770 | — | — | 1 | 6.90 |
| CHEMBL4204996 | — | — | 1 | 6.84 |
| CHEMBL3751951 | — | — | 1 | 6.47 |
| CHEMBL4205480 | — | — | 1 | 6.24 |
| CHEMBL4216182 | — | — | 1 | 5.59 |
| CHEMBL4208379 | — | — | 1 | 5.58 |
| CHEMBL4209929 | — | — | 1 | 5.47 |
| CHEMBL4213312 | — | — | 1 | - |
| CHEMBL4211120 | — | — | 1 | - |
| CHEMBL4207054 | — | — | 1 | - |
| CHEMBL4214346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217198 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4206444 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4212770 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4204996 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL3751951 | — | EC50 | = | 339.0 | nM | 6.47 |
| CHEMBL4205480 | — | EC50 | = | 578.0 | nM | 6.24 |
| CHEMBL4216182 | — | EC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL4208379 | — | EC50 | = | 2636.0 | nM | 5.58 |
| CHEMBL4209929 | — | EC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL4213312 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4211120 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4207054 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4214346 | — | EC50 | > | 10000.0 | nM | - |